Simparica Trio
Simparica Trio combines sarolaner, moxidectin and pyrantel in a single monthly oral chew that delivers broad-spectrum control of fleas, ticks, heartworm and common intestinal worms, making it a best-in-class option for owners who want one convenient product. Its technical advantage is the all-in-one oral formulation and strong tick and heartworm performance, which gives it an edge over products that lack tick activity (like Trifexis) or that are topical rather than oral (like Revolution Plus), while its competitive pricing and adherence benefits make it attractive to clinics focused on simplified prevention.
Triple-action chew
Rapid flea zap
Triple-action chew
Rapid flea zap
Review Summary
"Users generally praise Simparica Trio for reliably preventing fleas, ticks, heartworm and common intestinal parasites with once-monthly dosing; some owners report occasional mild side effects like vomiting or lethargy. Overall reviewers appreciate its broad protection and ease of use despite the occasional adverse reaction."
Pocket-rocket protection
Contains sarolaner, moxidectin and pyrantel for fleas, ticks, heartworm prevention and intestinal worm treatment.
Pocket-rocket protection
Contains sarolaner, moxidectin and pyrantel for fleas, ticks, heartworm prevention and intestinal worm treatment.
Increased Safety & Security
Time-Saving Convenience
Simparica Trio combines sarolaner, moxidectin and pyrantel in a single monthly oral chew that delivers broad-spectrum control of fleas, ticks, heartworm and common intestinal worms, making it a best-in-class option for owners who want one convenient product. Its technical advantage is the all-in-one oral formulation and strong tick and heartworm performance, which gives it an edge over products that lack tick activity (like Trifexis) or that are topical rather than oral (like Revolution Plus), while its competitive pricing and adherence benefits make it attractive to clinics focused on simplified prevention.
Triple-action chew
Rapid flea zap
Pocket-rocket protection
Contains sarolaner, moxidectin and pyrantel for fleas, ticks, heartworm prevention and intestinal worm treatment.
Monthly palatable chewable with rapid flea kill and reliable tick control.
Triple-action chew
Rapid flea zap
Pocket-rocket protection
Contains sarolaner, moxidectin and pyrantel for fleas, ticks, heartworm prevention and intestinal worm treatment.
Monthly palatable chewable with rapid flea kill and reliable tick control.
$200-260 USD
NexGard Spectra
NexGard Spectra pairs afoxolaner with milbemycin oxime to provide potent flea and tick control plus heartworm and intestinal parasite prevention in a palatable monthly chew, and it is often selected for its proven tick efficacy and broad parasite coverage. Technically it rivals Simparica Trio for comprehensive oral protection but uses a different isoxazoline (afoxolaner), which some veterinarians prefer for particular tick species; market penetration and distribution strength from its manufacturer also give it financial and availability advantages in many regions.
Beef-flavored treat
Broad parasite shield
Beef-flavored treat
Broad parasite shield
Review Summary
"NexGard Spectra is widely regarded as an effective, easy-to-administer chew that controls fleas, ticks and many intestinal parasites, with many owners noting rapid parasite control. A minority report stomach upset or rare neurological issues, but overall satisfaction is high."
Outdoor play enabler
Combines afoxolaner and milbemycin oxime to control fleas and ticks while preventing heartworm and treating intestinal parasites.
Outdoor play enabler
Combines afoxolaner and milbemycin oxime to control fleas and ticks while preventing heartworm and treating intestinal parasites.
Increased Safety & Security
Recreational Enjoyment
Time-Saving Convenience
NexGard Spectra pairs afoxolaner with milbemycin oxime to provide potent flea and tick control plus heartworm and intestinal parasite prevention in a palatable monthly chew, and it is often selected for its proven tick efficacy and broad parasite coverage. Technically it rivals Simparica Trio for comprehensive oral protection but uses a different isoxazoline (afoxolaner), which some veterinarians prefer for particular tick species; market penetration and distribution strength from its manufacturer also give it financial and availability advantages in many regions.
Beef-flavored treat
Broad parasite shield
Outdoor play enabler
Combines afoxolaner and milbemycin oxime to control fleas and ticks while preventing heartworm and treating intestinal parasites.
Monthly beef-flavored chewable that is easy to administer to most dogs.
Beef-flavored treat
Broad parasite shield
Outdoor play enabler
Combines afoxolaner and milbemycin oxime to control fleas and ticks while preventing heartworm and treating intestinal parasites.
Monthly beef-flavored chewable that is easy to administer to most dogs.
$150-210 USD
Trifexis
Trifexis combines spinosad and milbemycin oxime to deliver excellent oral adult flea control plus heartworm and intestinal worm prevention, making it a strong choice where fleas and internal parasites are the primary concern. Its limitation is a lack of tick coverage, so it is less comprehensive than Simparica Trio or NexGard Spectra for areas with tick-borne disease risk, but it can offer a cost-effective technical and financial alternative in low-tick environments or for owners prioritizing potent adulticide flea activity.
Chicken-flavored chew
Heartworm + fleas
Chicken-flavored chew
Heartworm + fleas
Review Summary
"Trifexis receives mixed reviews: many users appreciate its combined flea and intestinal parasite protection and monthly convenience, but a noticeable portion report vomiting, diarrhea or refusal to eat the tablet. Long-term users often switch if their dog has sensitivity or palatability problems."
Gut parasite zapper
Contains spinosad and milbemycin oxime to rapidly kill fleas while preventing heartworm and treating intestinal worms.
Gut parasite zapper
Contains spinosad and milbemycin oxime to rapidly kill fleas while preventing heartworm and treating intestinal worms.
Increased Safety & Security
Time-Saving Convenience
Trifexis combines spinosad and milbemycin oxime to deliver excellent oral adult flea control plus heartworm and intestinal worm prevention, making it a strong choice where fleas and internal parasites are the primary concern. Its limitation is a lack of tick coverage, so it is less comprehensive than Simparica Trio or NexGard Spectra for areas with tick-borne disease risk, but it can offer a cost-effective technical and financial alternative in low-tick environments or for owners prioritizing potent adulticide flea activity.
Chicken-flavored chew
Heartworm + fleas
Gut parasite zapper
Contains spinosad and milbemycin oxime to rapidly kill fleas while preventing heartworm and treating intestinal worms.
Monthly chewable that begins killing fleas quickly after administration.
Chicken-flavored chew
Heartworm + fleas
Gut parasite zapper
Contains spinosad and milbemycin oxime to rapidly kill fleas while preventing heartworm and treating intestinal worms.
Monthly chewable that begins killing fleas quickly after administration.
$140-200 USD
Revolution Plus for Dogs
Revolution Plus combines selamectin with sarolaner as a topical monthly treatment that extends protection to fleas, ticks, heartworm, mites and several intestinal parasites, giving it a technical advantage for mite control and for dogs that will not take oral chews. Compared with oral combos like Simparica Trio and NexGard Spectra, the topical route can improve owner convenience and tolerance in some pets, though it is sometimes priced higher and requires proper topical application to realize those benefits.
Topical monthly drop
Waterproof protection
Topical monthly drop
Waterproof protection
Review Summary
"Revolution Plus is commonly praised for its broad-spectrum protection including fleas, ticks, heartworm and several intestinal parasites with topical monthly application and good tolerability. Reviewers like the non-oral option and effectiveness, though some cite occasional skin irritation or lower palatability for dogs preferring oral meds."
Ear-mite zapper
Topical combination of selamectin and sarolaner offering protection against fleas, ticks, heartworm and common intestinal parasites.
Ear-mite zapper
Topical combination of selamectin and sarolaner offering protection against fleas, ticks, heartworm and common intestinal parasites.
Increased Safety & Security
Recreational Enjoyment
Time-Saving Convenience
Revolution Plus combines selamectin with sarolaner as a topical monthly treatment that extends protection to fleas, ticks, heartworm, mites and several intestinal parasites, giving it a technical advantage for mite control and for dogs that will not take oral chews. Compared with oral combos like Simparica Trio and NexGard Spectra, the topical route can improve owner convenience and tolerance in some pets, though it is sometimes priced higher and requires proper topical application to realize those benefits.
Topical monthly drop
Waterproof protection
Ear-mite zapper
Topical combination of selamectin and sarolaner offering protection against fleas, ticks, heartworm and common intestinal parasites.
Monthly water-resistant topical application that also helps control mites and some ear parasites.
Topical monthly drop
Waterproof protection
Ear-mite zapper
Topical combination of selamectin and sarolaner offering protection against fleas, ticks, heartworm and common intestinal parasites.
Monthly water-resistant topical application that also helps control mites and some ear parasites.
$160-230 USD
Sentinel Spectrum
Sentinel Spectrum pairs milbemycin oxime, lufenuron and praziquantel in a monthly chew that delivers heartworm prevention, comprehensive intestinal parasite control including tapeworms, and prevention of flea egg development, making it especially valuable when tapeworm or intestinal parasite coverage is a priority. Technically it does not kill adult fleas or ticks, so it is often used alongside an adulticide (or chosen where tick pressure is low), and financially it can be a cost-effective backbone product for clinics seeking strong internal parasite and tapeworm protection.
Flea-egg blocker
Pan-parasite tablet
Flea-egg blocker
Pan-parasite tablet
Review Summary
"Sentinel Spectrum is valued for preventing heartworm and a wide range of intestinal parasites (including tapeworms) and for supporting flea control via lufenuron, though it does not kill adult fleas quickly on its own. Users report reliable parasite prevention but note slower flea control compared with oral adulticides and occasional mild GI side effects."
Household-friendly guard
Combines milbemycin oxime, lufenuron and praziquantel to prevent heartworm, inhibit flea egg development and treat tapeworms.
Household-friendly guard
Combines milbemycin oxime, lufenuron and praziquantel to prevent heartworm, inhibit flea egg development and treat tapeworms.
Increased Safety & Security
Time-Saving Convenience
Sentinel Spectrum pairs milbemycin oxime, lufenuron and praziquantel in a monthly chew that delivers heartworm prevention, comprehensive intestinal parasite control including tapeworms, and prevention of flea egg development, making it especially valuable when tapeworm or intestinal parasite coverage is a priority. Technically it does not kill adult fleas or ticks, so it is often used alongside an adulticide (or chosen where tick pressure is low), and financially it can be a cost-effective backbone product for clinics seeking strong internal parasite and tapeworm protection.
Flea-egg blocker
Pan-parasite tablet
Household-friendly guard
Combines milbemycin oxime, lufenuron and praziquantel to prevent heartworm, inhibit flea egg development and treat tapeworms.
Monthly chewable provides broad intestinal parasite coverage including tapeworms not always covered by others.
Flea-egg blocker
Pan-parasite tablet
Household-friendly guard
Combines milbemycin oxime, lufenuron and praziquantel to prevent heartworm, inhibit flea egg development and treat tapeworms.
Monthly chewable provides broad intestinal parasite coverage including tapeworms not always covered by others.
$170-240 USD