Top 8 Intestinal Dewormers & Anthelmintics for Small Animals in the United States (2025): Vet-Recommended Options, Dosing Tips and Resistance Guidance

Milbemax is recognized for its cat-specific tablet formulations that combine reliable intestinal parasite coverage with smaller, feline-friendly dosing increments, making it a preferred choice for veterinary-prescribed feline deworming. Relative to Drontal Plus (dog-focused) and Profender (a premium feline option), Milbemax strikes a balance between targeted feline efficacy and affordability, often making it a practical clinic-stocked choice for routine cat parasite control.

Panacur is a best-in-class fenbendazole oral suspension known for a broad-spectrum activity and an excellent safety profile for small animals, making it a go-to for multi-day regimens against common intestinal nematodes. Compared with single-dose pyrantel products on this list, Panacur’s technical advantage is its wider parasite coverage and well-established clinical history, though it often requires a longer dosing course and sits in the mid-range price tier compared with cheaper single-dose alternatives.

Droncit Injectable (praziquantel) is the go-to injectable cestocide for treating intestinal tapeworms in small animals; its focused, high-efficacy action against tapeworms complements nematocide or benzimidazole therapies. Unlike the macrocyclic lactones (Ivomec, Dectomax, Noromectin) and fenbendazole (Panacur), Droncit fills the cestode niche and is often used in combination protocols—its targeted value justifies its role despite not addressing nematode or protozoal burdens on its own.

Interceptor Plus is a market leader because it pairs intestinal parasite control with proven monthly heartworm prevention, offering milbemycin oxime plus praziquantel in a palatable chew that simplifies comprehensive parasite protection. Technically and financially it carries a premium versus straight intestinal dewormers, but it delivers added value for owners seeking consolidated prevention against both intestinal worms and heartworm with one product.

Drontal Plus is positioned as a best-in-class oral broad‑spectrum dewormer for small animals thanks to its multi‑active formulation that targets tapeworms along with roundworms and hookworms. It stands out against single‑target options on this list by offering a cost‑efficient, single‑tablet approach for mixed infections and a palatable flavour that improves compliance versus harder‑to‑administer treatments. Compared with topical products like Profender, Drontal Plus is often the more economical and widely available oral choice when owners and veterinarians prefer tablets.

Panacur (fenbendazole) granules are a flexible, veterinary‑proven option for roundworm and hookworm control that can be dosed over multiple days and adjusted precisely for small or young animals, and are widely used where tailored regimens are preferred. While it typically requires several days of treatment unlike single‑dose chewables such as Drontal or Milbemax, Panacur's generic availability and ease of dose titration give it a financial and technical advantage for long or targeted treatment courses.

Zoetis' Revolution Plus is best‑in‑class for multi‑parasite protection because its topical combination targets both external pests (fleas, ticks, mites) and several internal parasites in a single monthly dose, streamlining prevention protocols. Technically it offers the broadest non‑oral protection among the products listed, which can simplify administration for owners and be cost‑effective for those seeking consolidated, monthly parasite control.