Top 6 Vitamin & Multivitamin Supplements for Reptiles and Amphibians in the USA 2025, Vet-Tested and Species-Specific Picks to Protect Their Health

Rep-Cal Herptivite Multivitamin is notable for its carefully balanced vitamin and mineral approach tailored to sensitive reptiles and amphibians, making it a go-to for keepers prioritizing nutritional completeness. Compared with the vitamin-forward Zoo Med or the spray-style Zilla, Rep-Cal emphasizes a broad micronutrient spectrum that can reduce the need for additional supplements, albeit often at a slightly higher price point reflecting its more comprehensive formulation.

Exo Terra Multi Vitamin Powder targets keepers who want a balanced, species-flexible multivitamin that integrates easily into dusting and soaking routines for both reptiles and amphibians. It competes by emphasizing formulation balance and ease of use—particularly useful for sensitive amphibians—positioning itself between budget options like Fluker's and the more specialized, premium mixes such as Repashy Calcium Plus.

Rep-Cal Calcium with D3 earns its place as a best-in-class calcium-focused supplement by delivering reliable, high-percentage calcium with measured vitamin D3 ideal for species that require frequent dusting. It is a cost-effective staple for keepers needing a straightforward calcium source, though it is less tailored in trace-mineral and species-specific micronutrient profiling than some specialized blends on this list.

Zoo Med Reptivite with D3 is a market leader thanks to its wide availability, inclusion of vitamin D3, and consistent, veterinarian-recognized formulation that makes it a go-to choice for general supplementation. While it is not a proprietary time-release system like Repashy, its economy of scale and broad distribution make it a financially attractive option for large-scale or entry-level keepers who need a reliable D3-containing powder without the premium price of specialized time-release products.

Oxbow Carnivore Care is a veterinary-grade recovery paste optimized for anorexic or convalescent carnivorous reptiles and amphibians, with a high-protein, easily digestible matrix and balanced electrolytes to support rehydration and rebuilding. It earns a market-leader mention in clinical feeding situations thanks to its formulation pedigree and proven efficacy in rehabilitative settings, though it is typically more expensive than general-use gels and is best reserved for medical or post-operative care rather than routine supplementation.