Top 7 Digestive Support & Probiotic Supplements for Horses in the USA (2025) — A Veterinarian-Informed Guide to Post-Deworming Recovery, Microbiome Balance and Choosing the Right Strain & Dose

Positioned as the best-in-class option for post-deworming recovery, BioEquine ProDigest Paste pairs a concentrated multi-strain probiotic blend with fast-acting mucoadhesive technology to help re-establish gut microflora after parasite treatment. It distinguishes itself by delivering high CFUs per dose at a competitive price, making it more cost-effective per treatment than many premium veterinary brands while offering broader strain coverage than single-strain, budget alternatives.

Mad Barn's Optimum Probiotic Pellets top this list for combining a high-CFU, multi-strain formula with a pelleted delivery designed for convenient, consistent dosing — attributes that make it especially useful as part of a preventive deworming support regimen. Compared with the powders and broader gastric-focused supplements here, Mad Barn strikes a balance between technical potency and barn-friendly handling, often commanding a mid-to-premium price justified by targeted equine formulations.

Webber Naturals Probiotic + Prebiotic earns its market‑leader placement by combining live microbial strains with prebiotic fiber into a single synbiotic formula, simplifying a post‑deworming regimen by delivering both recolonization agents and microbial fuel. Compared with bulk prebiotic powders and fermented whole‑food mixes on this list, it offers convenient dosing and generally lower per‑dose cost than premium clinical blends, though it lacks the organic whole‑food profile of some powdered options.

Purina SuperSport Digestive Health leverages Purina’s extensive research and distribution network to deliver a vet-backed supplement tailored for performance animals, providing reliable digestive enzyme support alongside proprietary delivery systems. While typically priced higher than specialist enzyme products such as Mad Barn or Martin Mills, Purina’s technical advantage is its integration with established performance feeding programs and widespread availability for trainers and competitive stables.

Bio-K+ occupies a best-in-class position for synbiotic support after deworming because it pairs high-potency, well-characterized probiotic strains with a formulation designed for rapid gut repopulation; compared with the other products listed, it typically commands a premium price that reflects its clinical positioning and specialty manufacturing. Its technical advantage is a focus on strain stability and immediate colonization, making it suitable when a practitioner prioritizes evidence-backed probiotic strains for early post-deworming recovery rather than lower-cost, lower-potency options.

Designs for Health GI‑Revive is a comprehensive mucosal‑repair formula combining amino acids, botanicals and demulcent agents to support epithelial healing after parasite treatment; it stands out technically for its broad nutrient matrix tailored to barrier repair. While often priced higher than single‑ingredient options, its wide coverage can make it financially efficient by limiting the need to purchase multiple separate supplements for repair and soothing.