Zylkene Capsules for Dogs
Zylkene holds a best-in-class position for peptide-based calming because it delivers a purified milk-derived peptide (alpha-casozepine) with a non-sedating, mechanism-driven effect that many clinicians prefer for long-term anxiety management. Compared with the other amino-acid and botanical-focused options in this list, Zylkene’s distinct peptide technology offers a targeted pharmacologic approach that can reduce reliance on pharmaceuticals — a technical advantage that can translate to lower overall treatment cost for chronic cases despite a premium per-unit price.
Milk-protein calm — moo
Non-drowsy ease
Milk-protein calm — moo
Non-drowsy ease
Review Summary
"Users report Zylkene gently reduces mild anxiety and stress in many dogs with minimal side effects, though it can take several days to weeks and may not be strong enough for severe cases."
Openable capsules
Contains alpha-casozepine, a milk‑derived peptide shown to promote calm in dogs.
Openable capsules
Contains alpha-casozepine, a milk‑derived peptide shown to promote calm in dogs.
Increased Safety & Security
Zylkene holds a best-in-class position for peptide-based calming because it delivers a purified milk-derived peptide (alpha-casozepine) with a non-sedating, mechanism-driven effect that many clinicians prefer for long-term anxiety management. Compared with the other amino-acid and botanical-focused options in this list, Zylkene’s distinct peptide technology offers a targeted pharmacologic approach that can reduce reliance on pharmaceuticals — a technical advantage that can translate to lower overall treatment cost for chronic cases despite a premium per-unit price.
Milk-protein calm — moo
Non-drowsy ease
Openable capsules
Contains alpha-casozepine, a milk‑derived peptide shown to promote calm in dogs.
Available in capsules that can be given whole or opened and mixed with food for easy dosing.
Milk-protein calm — moo
Non-drowsy ease
Openable capsules
Contains alpha-casozepine, a milk‑derived peptide shown to promote calm in dogs.
Available in capsules that can be given whole or opened and mixed with food for easy dosing.
$30-80 USD
Purina Pro Plan Veterinary Supplements Calming Care
Purina Pro Plan Veterinary Supplements Calming Care is a market-leading amino-acid focused option because it pairs clinically oriented formulation with Purina’s scale and veterinary distribution, making it widely available and often the most cost-effective choice for routine calming support. Versus boutique peptide or premium veterinary-only brands on this list, Purina’s financial advantage is predictable retail pricing and broad vet endorsement, while its technical strength lies in formulation and feeding-trial-backed development.
Amino-acid based
Treat-like delight
Amino-acid based
Treat-like delight
Review Summary
"Most buyers find Purina Pro Plan Veterinary Calming Care reasonably effective for situational anxiety and easy to dose, but some say it offers only modest benefit compared with stronger options."
Veterinary-formula
Veterinary-formulated supplement focused on behavior support using amino acids such as gal-tryptophan.
Veterinary-formula
Veterinary-formulated supplement focused on behavior support using amino acids such as gal-tryptophan.
Increased Safety & Security
Recreational Enjoyment
Time-Saving Convenience
Purina Pro Plan Veterinary Supplements Calming Care is a market-leading amino-acid focused option because it pairs clinically oriented formulation with Purina’s scale and veterinary distribution, making it widely available and often the most cost-effective choice for routine calming support. Versus boutique peptide or premium veterinary-only brands on this list, Purina’s financial advantage is predictable retail pricing and broad vet endorsement, while its technical strength lies in formulation and feeding-trial-backed development.
Amino-acid based
Treat-like delight
Veterinary-formula
Veterinary-formulated supplement focused on behavior support using amino acids such as gal-tryptophan.
Tablet format dosed by weight for daily or sustained use under veterinary guidance.
Amino-acid based
Treat-like delight
Veterinary-formula
Veterinary-formulated supplement focused on behavior support using amino acids such as gal-tryptophan.
Tablet format dosed by weight for daily or sustained use under veterinary guidance.
$25-60 USD
VetriScience Composure Pro Chews
VetriScience Composure Pro Chews earns a top position for delivering concentrated amino-acid support in a palatable, chewable format designed for acute stress events and everyday anxiety; this product emphasizes convenient administration and high owner compliance. Compared with powder or capsule competitors here, its technical advantage is a flavor-forward chew and often higher per-dose potency—making it a premium but practical choice for dogs that refuse pills or require fast-acting oral delivery.
Clinically-backed calm
Fast-acting chews
Clinically-backed calm
Fast-acting chews
Review Summary
"Owners generally praise VetriScience Composure Pro Chews as palatable and often fast-acting for travel and noise-related anxiety, though a minority report limited effect on severe, chronic issues."
Lab-coat calm
Features clinically studied gal-theanine (Suntheanine) to promote relaxation without sedation.
Lab-coat calm
Features clinically studied gal-theanine (Suntheanine) to promote relaxation without sedation.
Increased Safety & Security
Time-Saving Convenience
VetriScience Composure Pro Chews earns a top position for delivering concentrated amino-acid support in a palatable, chewable format designed for acute stress events and everyday anxiety; this product emphasizes convenient administration and high owner compliance. Compared with powder or capsule competitors here, its technical advantage is a flavor-forward chew and often higher per-dose potency—making it a premium but practical choice for dogs that refuse pills or require fast-acting oral delivery.
Clinically-backed calm
Fast-acting chews
Lab-coat calm
Features clinically studied gal-theanine (Suntheanine) to promote relaxation without sedation.
Palatable soft chews that are easy to give daily or during acute stress events like fireworks or travel.
Clinically-backed calm
Fast-acting chews
Lab-coat calm
Features clinically studied gal-theanine (Suntheanine) to promote relaxation without sedation.
Palatable soft chews that are easy to give daily or during acute stress events like fireworks or travel.
$45-85 USD
NaturVet Quiet Moments Calming Aid
NaturVet Quiet Moments is positioned as the value leader among amino-acid and calming supplements by combining basic amino acids and calming botanicals into an accessible, budget-friendly formula for owners exploring non-prescription options. While it generally lacks the clinical depth of peptide-focused or veterinary-grade alternatives on this list, its financial advantage is clear: lower cost of entry and widespread retail availability, which makes it a sensible first-line trial for mild situational anxiety.
Herbal-amino blend
Nighttime gentle calm
Herbal-amino blend
Nighttime gentle calm
Review Summary
"Quiet Moments is regarded as an affordable calming aid that helps some dogs relax, but reviews are mixed with many users reporting little to no change for more serious anxiety."
Budget-friendly zzz
Economical chewable option designed for situational calming and short-term stress relief.
Budget-friendly zzz
Economical chewable option designed for situational calming and short-term stress relief.
Increased Safety & Security
Recreational Enjoyment
NaturVet Quiet Moments is positioned as the value leader among amino-acid and calming supplements by combining basic amino acids and calming botanicals into an accessible, budget-friendly formula for owners exploring non-prescription options. While it generally lacks the clinical depth of peptide-focused or veterinary-grade alternatives on this list, its financial advantage is clear: lower cost of entry and widespread retail availability, which makes it a sensible first-line trial for mild situational anxiety.
Herbal-amino blend
Nighttime gentle calm
Budget-friendly zzz
Economical chewable option designed for situational calming and short-term stress relief.
Formulated for easy administration and broad availability in pet stores and online.
Herbal-amino blend
Nighttime gentle calm
Budget-friendly zzz
Economical chewable option designed for situational calming and short-term stress relief.
Formulated for easy administration and broad availability in pet stores and online.
$12-30 USD
Nutramax Solliquin Behavioral Health Supplement
Nutramax Solliquin is regarded as a veterinary-grade market leader for behavioral health because it integrates amino-acid support with a proprietary complementary blend aimed at mood and coping behaviors, backed by Nutramax’s veterinary distribution and product support. Compared with simpler OTC or single-ingredient options in this list, Solliquin’s technical advantage is its vet-focused dosing and formulation rigor; financially, it occupies a premium segment but can reduce the need for prescription drugs in some patients, offering long-term value for complex cases.
Dual amino blend
Behavioral support long-term
Dual amino blend
Behavioral support long-term
Review Summary
"Solliquin is frequently recommended by veterinarians and reviewers for reliably reducing separation and noise-related anxiety, though it’s more expensive and can take a week or more to show full effect."
Science-meets-zen
Veterinary-grade behavioral supplement combining targeted amino acids and peptide support for mood regulation.
Science-meets-zen
Veterinary-grade behavioral supplement combining targeted amino acids and peptide support for mood regulation.
Increased Safety & Security
Self-Improvement & Personal Growth
Nutramax Solliquin is regarded as a veterinary-grade market leader for behavioral health because it integrates amino-acid support with a proprietary complementary blend aimed at mood and coping behaviors, backed by Nutramax’s veterinary distribution and product support. Compared with simpler OTC or single-ingredient options in this list, Solliquin’s technical advantage is its vet-focused dosing and formulation rigor; financially, it occupies a premium segment but can reduce the need for prescription drugs in some patients, offering long-term value for complex cases.
Dual amino blend
Behavioral support long-term
Science-meets-zen
Veterinary-grade behavioral supplement combining targeted amino acids and peptide support for mood regulation.
Often recommended for chronic anxiety and behavioral issues and used as part of a multi-modal treatment plan.
Dual amino blend
Behavioral support long-term
Science-meets-zen
Veterinary-grade behavioral supplement combining targeted amino acids and peptide support for mood regulation.
Often recommended for chronic anxiety and behavioral issues and used as part of a multi-modal treatment plan.
$55-120 USD